All lanes of traffic are now open on southbound Highway 160 at Tracker Road in Nixa after being shut down Thursday afternoon following a bad crash.
Nixa City Spokesman Drew Douglas says a semi truck crashed into the side of a compact blue sedan.
One person was rushed to a local hospital with serious injuries.
During the closure, drivers were asked to take Highway CC to Main Street to Aldersgate to return to southbound 160.
All lanes re-opened by 3:00 p.m.