Four people were killed in a two-vehicle crash on U-S 54 near Walker in Vernon County Friday night.
The Highway Patrol says a car failed to stop at a stop sign and was struck by an S-U-V.
The car ran off the road and struck a fence and a tree.
Three women in the car and the man driving the S-U-V died at the scene.
The Highway Patrol says one of the victims was from Springfield.
The man driving the car and another woman passenger are hospitalized with serious injuries.
The women who died, were employed by the Climax Springs R-4 School District in Camden County, attending a basketball game in the area.